dna inspectorIntroduction to Bioinformatics

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Explore NCBI (movie)
Pick a Gene (movie)
Gene Identifiers (movie)
Link to a Disease (movie)
DNA Structure on a Chromosome (movie)
RNA Structure During Transcription and Translation (movie)
Protein Structure-Including Domains (movie)
Occurance in Diverse Organisms (movie)
Evolution (movie)
Save a Search This movie illustrates using the My NCBI feature of the NCBI website to save database searches.
Chromosome 11 Tour This is a "flyover" of the tip of the short arm of human chromosome 11 covers about 650,000 nucleotides. Genes, introns, exons, and transposons are all color coded. A great overview that brings visual substance to DNA science.
Human Genome Geography is a set of graphics depicting the sequence and rough locations of genes. Each chromosome is done on one page. Similar to a map with the names of the cities.
Online Mendelian Inheritance in Man (OMIM) This database is a catalog of human genes and genetic disorders. The database contains textual information and references. It also contains copious links to MEDLINE and sequence records in the Entrez system, and links to additional related resources at NCBI and elsewhere.
Microarrays MediaBook A snazzy animated tutorial on the basics of microarrays. Using the example of yeast cells growing with and without oxygen, the site leads readers through the basics of making and interpreting microarrays. One can then dig deeper into techniques for analyzing results. Lessons include learning about hierarchical clustering to identify genes that might work together.
  Advance Announcement Electronic flyer with brief description of this class which is scheduled to commence in Spring 2007.
  DNA Movies
  DNA Restriction Technology A slide show that explains The discovery of enzymes that could cut and paste DNA made genetic engineering possible. Restriction enzymes, found naturally in bacteria, can be used to cut DNA fragment at specific sequences, while another enzyme, DNA ligase, can attach or rejoin DNA fragments with complementary ends.
  Polymerase Chain Reaction This slide show explains Polymerase chain reaction (PCR), a process that enables researchers to produce millions of copies of a specific DNA sequence in approximately two hours. This automated process bypasses the need to use bacteria for amplifying DNA.
  Model Organisms for genetic and molecular biology experiments. A cartoon depiction of the primary model organisms with descriptions of their individual advantages and disadvantages.
  Genomic Medicine Database This (to be opened in October 2006) website will showcase such results from 1320 participants in the famed Framingham Heart Study, which has followed the health of a small Massachusetts town for 50 years. You can peruse the chromosomes for possible associations between about 10 traits--such as hypertension and high cholesterol levels--and 100,000 genetic markers, known as SNPs.
  Bioinformatics Educational Resource at EBI, AKA Bioinformatics for Dummies This site provides short and concise introductions to basic concepts in molecular and cell biology and bioinformatics. The main emphasis is placed on making it as easy as possible for the user to understand which tools and databases are available from the EBI and from sites belonging to its collaborators. The site content aims to make these services easier and more accessible but also provides links to other sites where similar resources are maintained and well supported.

Sequence Comparison Primer

  Sequence Comparison Lesson
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